The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis
نویسندگان
چکیده
منابع مشابه
The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis
The recently completed European trial of interferon betahad a greater reduction of cerebral volume in the placebo group (mean reduction at month 36: placebo 5.1%, IFNβ1b (IFNβ-1b) in patients with secondary progressive 1b 1.8%, P < 0.05) whereas those with Gd-enhancing multiple sclerosis (SP multiple sclerosis) has given an lesions showed a trend to greater reduction of cerebral opportunity to ...
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Recently, the clinical efficacy of interferon beta-1b (IFNbeta-1b) was demonstrated for secondary progressive (SP) multiple sclerosis in a European multicentre study. We evaluated the effect of IFNbeta-1b treatment on the rate of development of hypointense T(1) MRI lesions, a putative marker of axonal damage. Unenhanced T(1)-weighted images were obtained in a subgroup of 95 multiple sclerosis p...
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Recent studies of the spinal cord and cerebellum have highlighted the importance of atrophy in the development of neurological impairment in multiple sclerosis. We have therefore developed a technique to quantify the volume of another area commonly involved pathologically in multiple sclerosis: the cerebral white matter. The technique we describe extracts the brain from the skull on four contig...
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BACKGROUND AND PURPOSE Beta-interferons (IFNβ) are the most widely prescribed drugs for patients with multiple sclerosis (MS). However, whether or not treatment with IFNβ can delay secondary progressive MS (SPMS) onset remains unknown. Our aim was to examine the association between IFNβ exposure and SPMS onset in patients with relapsing-remitting MS (RRMS). METHODS A retrospective cohort stud...
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ژورنال
عنوان ژورنال: Brain
سال: 2000
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/123.11.2256